Bufo / 5-MEO-DMT

“Apparently, then, our lifelong nostalgia, our longing to be reunited with something in the universe from which we now feel cut off, to be on the inside of some door which we have always seen from the outside, is no mere neurotic fancy, but the truest index of our real situation. And to be at last summoned inside would be both glory and honor beyond all our merits and also the healing of that old ache.”

C.S. Lewis, The Weight of Glory

Have You Ever Felt Like Something’s Missing?

Not FOMO the fear of missing out. 

But the subtle sense that there is something in the universe we have been cut off from. You aren’t crazy. Everyone feels it. No one talks about it. It’s true. 

There is a connection that your soul is missing. More adventures, drugs, a nicer car or house to show off are all ways we try to cure this ache. We try to keep up with the jones’s. And yet we still can’t find that connection we are only vaguely aware of. 

Everything society has told us about how to ‘succeed’ has sent us in the wrong direction. You will never find the answer “out there” Fame, fortune. 

Everything you need is already inside of you. Everything. 

What Is 5-MeO-DMT?

5-MeO-DMT, sometimes called “the God Molecule,” is a natural psychedelic that provides one of the most powerful spiritual experiences known. Many describe it as a moment of “ego death,” where you let go of the part of yourself that holds on to fear, control, and separation. In this state, people often feel an overwhelming sense of peace, connection, and unity with the universe.

Why Try 5-MeO-DMT?

A single experience with 5-MeO-DMT can have profound effects, including:

  • Improved well-being and mindfulness
  • Relief from anxiety, depression, and past trauma
  • Freedom from negative thought patterns and behaviors
  • Increased clarity, motivation, and inner peace
  • A deep sense of connection to the universe or “divine”
  • Healing stored pain and emotional blocks

Many describe the experience as life-changing—like “melting into love” or feeling at one with all existence.

Where Does 5-MeO-DMT Come From?

The compound is naturally found in the venom of the Sonoran Desert Toad (Bufo alvarius), which lives in the southwestern United States and Mexico. While some people insist on using organic toad venom, synthetic versions work just as well, and both are safe when used correctly.

What to Expect During the Experience

The Process:

  • How It’s Taken: 5-MeO-DMT is vaporized and inhaled through a glass pipe.
  • How It Feels: Effects start within 30 seconds, peak for about 15 minutes, and taper off within 30 minutes.
  • Dosages:
    • Microdose (10–15 mg): Gentle, peaceful effects
    • Moderate dose (20–25 mg): More intense emotional and physical sensations
    • Full dose (50–100 mg): Profound ego death and mystical experiences

What You Might Feel:

  • A deep sense of calm or euphoria
  • Loss of physical awareness or control
  • A feeling of vibrating, heaviness, or lightness in your body
  • Intense emotions—ranging from fear to bliss
  • A sense of being one with the universe
  • Memories or feelings surfacing from your subconscious

While the experience can feel intense, it’s often described as deeply healing and transformative.

Preparing for a 5-MeO-DMT Session

  • What to Wear: Comfortable, stretchy clothes. Avoid dresses or anything rest
    rictive.
  • Food: Eat lightly or avoid food for 3–4 hours before. If you eat, stick to something simple like fruit.
  • Set an Intention: Think about what you’d like to let go of or gain clarity on, but be open to unexpected insights.
  • The Setting: You’ll lie on a soft mat in a peaceful room, surrounded by music designed to guide the experience.

Types of Sessions Group (2-4 people being served at a time)

  1. Micro Circle ($100):
    A gentle group experience with small doses. Three rounds of 10mg allow you to feel peaceful and calm or undergo a light emotional cleanse.
  1. Ego Liberation / Full Ride ($250):
    A personal journey through increasing doses. This session aims for the “full” mystical experience—complete ego death and profound insight. One serving of 10mg, 25mg and potentially several servings for 50mg+. 

Types of Sessions Individual Private session (2 Hours)

Micro Circle ($250):

A gentle individual experience with small doses. Three rounds of 10mg allow you to feel peaceful and calm or undergo a light emotional cleanse.

  1. Ego Liberation / Full Ride ($500):
    A personal journey through increasing doses. This session aims for the “full” mystical experience—complete ego death and profound insight. One serving of 10mg, 25mg and potentially several servings for 50mg+. 
  1. Blooming Flower ($3,000-5,000):

The blooming flower is a special Bufo ceremony. Bufo is administered continuously for 1-3 hours.

How It Works

  • Continuous Doses: You’ll go through 20-60 doses of 5-MeO-DMT.
  • Increasing Doses: The first dose starts small (10 micrograms) and gradually increases the entire ceremony.
  • Quick Transitions: right as the previous dose is about to subside another dose is offered.

What Happens if You Need to Stop?

  • If you’re unable to take the next dose when it’s offered, the ceremony ends.

Blooming Flower with Bufo is an intense but rewarding experience that helps clear energetic blockages and balance your body and mind. It’s designed for those seeking deeper emotional and spiritual alignment.

Why People Choose 5-MeO-DMT

For some, it’s a tool for spiritual growth and self-discovery. For others, it’s about healing—letting go of trauma, breaking free from anxiety or depression, and reconnecting with life in a meaningful way.

If you’ve been searching for something deeper, 5-MeO-DMT might be the key to unlocking what’s already inside you.

The Risks

 

Studies show that 5-MeO-DMT is generally safe when used responsibly, but there are important things to consider before trying it:

  • Medication Interactions: Never mix 5-MeO-DMT with antidepressants (especially MAOIs) or ADHD medications. This can cause dangerous side effects like high blood pressure, seizures, or serotonin syndrome.
  • Facilitator Matters: Always work with an experienced guide. The experience can be intense, and facilitators are there to keep you safe and help you process what happens.
  • Physical Effects: Some people may lose coordination, feel short of breath, or even faint briefly. These effects are temporary but can feel overwhelming without proper guidance.
  • Individual Reactions: Everyone’s body reacts differently. Even if you’ve tried other psychedelics, it’s best to start with a small “microdose” to gauge your response.

The Benefits

5-MeO-DMT has been used for both healing and personal growth. Some of its potential benefits include:

  • Mental Health: It can help reduce anxiety, depression, PTSD, and addiction. Some people experience relief from long-standing emotional pain after just one session.
  • Physical Relief: Many report feeling long-term pain relief or reduced inflammation.
  • Personal Growth: It’s often described as a “rebirth,” helping people let go of old fears and find clarity, peace, and motivation.
  • Spiritual Exploration: The experience can feel like connecting with the universe or discovering a deep sense of unity and purpose.

Therapeutic Uses

5-MeO-DMT is being studied for its ability to:

  • Heal Trauma: It may release stored emotional and physical pain.
  • Break Addictions: Studies suggest it can reduce cravings and withdrawal symptoms.
  • Improve Mental Clarity: Many users feel more focused and motivated after their experience.
  • Support Integration: It’s sometimes used after ceremonies like Ayahuasca to help people process their insights and emotions.

Personal Growth and Spiritual Exploration

Many people use 5-MeO-DMT to explore deeper questions about life and their place in the universe. While the experience can be intense, it’s often described as life-changing. Benefits include:

  • A sense of peace and joy in daily life
  • Letting go of fear, especially fear of death
  • Healing from negative patterns or past pain
  • Feeling connected to something bigger than yourself

What to Expect Legally

In the U.S., 5-MeO-DMT is a Schedule I controlled substance, meaning it’s illegal to produce, sell, or possess. However, some spiritual organizations use it as part of their religious practices, and it has been decriminalized in certain areas, like Oakland, California.

Sustainability of Toad Venom

5-MeO-DMT is naturally found in the venom of the Sonoran Desert Toad. While some prefer organic toad venom, synthetic 5-MeO-DMT is just as effective and doesn’t harm the toad population. Responsible use ensures the medicine is sustainable for future generations.

Common Myths

  • “It’s the same as DMT.” Not true. 5-MeO-DMT focuses on emotional and spiritual sensations, while DMT is more visual.
  • “You can lick a toad to feel its effects.” Don’t do this! Toad venom must be properly vaporized to be safe and effective.

FAQs

  1. Can it show up on a drug test?
    No, 5-MeO-DMT is not detected in standard drug tests.
  2. Can it cause long-term harm?
    Not when used responsibly with an experienced guide. Some people may feel overwhelmed, but this is temporary.
  3. Can I microdose?
    Yes, but even small doses can feel powerful. Most people experience either intense peace or emotional cleansing.
  4. Can I mix it with other substances?
    No. Mixing it with medications like antidepressants or stimulants is dangerous and can lead to severe side effects. Avoid alcohol or recreational drugs before a session.

Is It Safe?

When used with a skilled facilitator, 5-MeO-DMT is generally safe. However, it should never be mixed with certain medications, like antidepressants (SSRIs) or MAOIs, as this can cause serious health risks. Be sure to discuss any medications or health concerns with your facilitator beforehand.

Instructions for Your Bufo Experience

  1. Get Comfortable:
    Sit cross-legged on the mat provided. Take a moment to settle yourself and focus on your breathing.
  2. Prepare Your Breath:
    Take three big breaths, paying special attention to the exhale. Push all the air out of your lungs each time. This isn’t slow or meditative breathing—it’s about moving the air fully.
    After your third exhale, give a small nod to signal you’re ready.
  3. Taking the Medicine:
    • A facilitator will bring the pipe to your lips, so you won’t need to move your head.
    • Take a slow, steady draw from the pipe for about 20 to 30 seconds. Imagine sipping through a coffee straw.
    • The slower and more controlled your breath, the better the medicine will vaporize and reach you.
    • Once you’re full, hold your breath for as long as feels comfortable. No need to count—just follow your instincts.
    • When you’re ready, exhale slowly. The effects will start as you breathe out.
  4. What Happens Next:
    • You may choose to stay seated or lie down on the mat. Most people prefer lying down for comfort.
    • If you lie down, try to keep your body balanced (e.g., both arms in similar positions, legs uncrossed). Twisting or squirming can sometimes feel like your mind resisting the experience. Let yourself relax fully.
  5. Letting Go:
    Bufo works on a deep subconscious level, unlike most psychedelics that affect conscious thoughts.

    • Feel the experience. You might notice emotions, memories, or sensations arise.
    • Avoid overthinking or analyzing during the journey. If questions pop up—like “What does this mean?” or “What do I do about this?”—let them drift away.
    • Imagine the memories or feelings as the sound of a bell fading. Don’t hold on; just observe and let go.
  6. Tips for a Smoother Experience:
    • The more you relax and let go, the easier the process will be.
    • Thinking too much can make the journey harder. Trust the experience and allow it to flow naturally.

This is your time to explore, release, and connect. Let go of expectations and let the medicine guide you.

5-MeO-DMT is found in the milky white venom of the Sonoran Desert Toad (Bufo alvarius/Incilius alvarius; aka the Colorado River Toad ), which isnative to the southwestern United States and northwestern Mexico. 

Because of our heritage and association with the Sonoran Desert Toad we use organic 5-MEO-DMT. In our experience there is no difference in outcomes between organic 5-MEO-DMT & Synthetic. 

 

Setting

The room that you enter into will be set up with several soft mats arranged around the floor there will be anywhere from three to six mats. If you’re waiting your turn you’re welcome to wait in the room and observe other people’s experiences as long as you do so quietly. We ask that you not have any conversations or be on your phone. And that if you’re there to observe that you witness and hold space for those in the experience, if you’d like to wait outside of the room, you’re welcome to do that as well when it’s your turn, we will come gather you and escort you in 

 

Music

Music is being played throughout the experience. 

There is a specific playlist for the chakra alignment. 

The ‘playlist’ for bufo ceremonies is a collection of about 2000 songs. 

The playlist is played on random shuffle being guided by spirit and it almost always ends up being perfect. 

In five years of trusting spirit the song is always perfect. 

 

5-MeO DMT and the Sustainability of the Sonoran Desert Toad

We use organic toad venom (Bufo)  as our source of 5-MeO-DMT. We use toad venom because we live in the toad’s natural habitat. If we lived in the northern US, we would utilize synthetic 5-MEO-DMT. 

In the US the Bufo Alvarius toad population is strained. In Mexico (where we source our medicine, from the Siri Indians) the toads are plentiful and abundant. There is no need for the toad population to be altered by being “milked” of their venom. The popularity of 5-MEO-DMT and harvesting it mindfully will not have an impact on the Bufo Toad population. 

As the popularity of 5-MEO-DMT grows and becomes popular world wide it won’t be possible for the toad population to produce enough venom for everyone.  

There are two camps of people “purity” people believe that organic toad venom is superior and has a superior outcome. “Save the Earth” people think synthetic 5-MEO-DMT will save the toads and is just as good as organic. 

We disagree with both groups. 

Many people believe toad medicine is superior because of its “purity”, but there is no evidence that 5-MeO-DMT derived from toads produces a better/different experience or outcome than synthetic 5-MeO-DMT.

As a facilitator I’ve experienced both organic and synthetic. There is no difference in effect or outcome. If there is a difference it is so insignificant as to be not worth mentioning.